The Signal Peptide Sequence Impacts the Immune Response Elicited by a DNA Epitope Vaccine-Reference-Cited by-同舟云学术

The Signal Peptide Sequence Impacts the Immune Response Elicited by a DNA Epitope Vaccine

Published:2011-08-10 Issue:10 Volume:18 Page:1776-1780
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin. Vaccine Immunol.

Author:

Vatakis Dimitrios,McMillan Minnie

Abstract

ABSTRACTWe examined the effect of two leader sequences, one from a transmembrane molecule (H2-Ld) and another from a secreted molecule (rat KC chemokine), on the immunogenicity of DNA epitope vaccines. The chemokine leader enhanced vaccine immunogenicity, thus underscoring the importance of the leader sequence in DNA epitope vaccine design.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

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