Efficient Treatment of Experimental Cerebral Malaria by an Artemisone-SMEDDS System: Impact of Application Route and Dosing Frequency-Reference-Cited by-同舟云学术

Efficient Treatment of Experimental Cerebral Malaria by an Artemisone-SMEDDS System: Impact of Application Route and Dosing Frequency

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zech Johanna¹^ORCID,Salaymeh Nadeen²,Hunt Nicholas H.³,Mäder Karsten¹^ORCID,Golenser Jacob²

Affiliation:

1. Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

2. Department of Microbiology and Molecular Genetics, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem, Jerusalem, Israel

3. Discipline of Pathology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, Australia

Abstract

Artemisone (ART) has been successfully tested in vitro and in animal models against several diseases. However, its poor aqueous solubility and limited chemical stability are serious challenges.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02106-20

Reference92 articles.

1. WHO Global Malaria Programme. 2015. Guidelines for the treatment of malaria, 3rd edition. WHO, Geneva, Switzerland.

2. Challenges to replace ACT as first-line drug

3. OUP accepted manuscript