Uptake and Intracellular Activity of Linezolid in Human Phagocytes and Nonphagocytic Cells-Reference-Cited by-同舟云学术

Uptake and Intracellular Activity of Linezolid in Human Phagocytes and Nonphagocytic Cells

Published:2002-12 Issue:12 Volume:46 Page:4013-4015
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pascual Álvaro¹,Ballesta Sofía¹,García Isabel¹,Perea Evelio J.¹

Affiliation:

1. Department of Microbiology, School of Medicine, University of Seville, Seville, Spain

Abstract

ABSTRACT The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ones in both types of cell. The uptake was rapid and not saturable and was affected by environmental temperature and cell viability. Linezolid showed slight intracellular activity against Staphylococcus epidermidis at high extracellular concentrations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.12.4013-4015.2002

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