DNA Sequence Analysis of DNA Gyrase and DNA Topoisomerase IV Quinolone Resistance-Determining Regions of Salmonella enterica Serovar Typhi and Serovar Paratyphi A-Reference-Cited by-同舟云学术

DNA Sequence Analysis of DNA Gyrase and DNA Topoisomerase IV Quinolone Resistance-Determining Regions of Salmonella enterica Serovar Typhi and Serovar Paratyphi A

Published:2002-10 Issue:10 Volume:46 Page:3249-3252
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hirose Kenji¹,Hashimoto Ai¹,Tamura Kazumichi¹,Kawamura Yoshiaki²,Ezaki Takayuki²,Sagara Hiroko³,Watanabe Haruo¹

Affiliation:

1. Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640

2. Department of Microbiology, Gifu University, School of Medicine, 40 Tsukasa-machi, Gifu, 500-8750

3. Department of Infectious Diseases, Yokohama City Hospital, 56 Okazawa-cho, Hodogaya, Yokohama City, Kanagawa, 240-8555, Japan

Abstract

ABSTRACT The mutations that are responsible for fluoroquinolone resistance in the gyrA , gyrB , parC , and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the gyrB , parC , and parE genes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.10.3249-3252.2002

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