Expression of SHV-2 β-Lactamase and of Reduced Amounts of OmpK36 Porin in Klebsiella pneumoniae Results in Increased Resistance to Cephalosporins and Carbapenems-Reference-Cited by-同舟云学术

Expression of SHV-2 β-Lactamase and of Reduced Amounts of OmpK36 Porin in Klebsiella pneumoniae Results in Increased Resistance to Cephalosporins and Carbapenems

Published:2002-11 Issue:11 Volume:46 Page:3679-3682
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Crowley Brendan¹,Benedí Vicente J.²,Doménech-Sánchez Antonio²

Affiliation:

1. Public Health Laboratory, University Hospital Aintree, Liverpool L9 7AL, United Kingdom

2. Laboratorio de Microbiología, Instituto Mediterráneo de Estudios Avanzados (IMEDEA, CSIC-UIB), Universitat de les Illes Balears, 07071-Palma de Mallorca, Spain

Abstract

ABSTRACT A Klebsiella pneumoniae clinical isolate was resistant to cefoxitin, cefotaxime, ceftazidime, ceftazidime-clavulanate, piperacillin-tazobactam (MICs, >256 μg/ml in all cases), and meropenem (MIC, 16 μg/ml) and was intermediate to imipenem (MIC, 8 μg/ml). Decreased expression of the OmpK36 porin and expression of an SHV-2 β-lactamase contributed to the observed resistance to these β-lactam-containing agents.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.11.3679-3682.2002

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