−11 Mutation in the ampC Promoter Increasing Resistance to β-Lactams in a Clinical Escherichia coli Strain-Reference-Cited by-同舟云学术

−11 Mutation in the ampC Promoter Increasing Resistance to β-Lactams in a Clinical Escherichia coli Strain

Published:2002-10 Issue:10 Volume:46 Page:3265-3267
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Corvec S.¹,Caroff N.²,Espaze E.¹,Marraillac J.¹,Reynaud A.²

Affiliation:

1. Laboratoire de Bactériologie-Virologie, Hygiène hospitalière, CHU

2. Laboratoire de Bactériologie-Virologie, Faculté de Pharmacie, Université de Nantes, Nantes, France

Abstract

ABSTRACT A mutation was discovered in the Pribnow box of the ampC promoter in a clinical Escherichia coli strain. This −11 C-to-T transition created a perfect homology with the −10 consensus sequence. The new promoter was cloned upstream of the cat gene of pKK232-8 and induced a sixfold increase in promoter strength.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.10.3265-3267.2002

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