Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration-Reference-Cited by-同舟云学术

Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration

Published:2022-10-18 Issue:10 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Byers Isabelle S.¹^ORCID,Turner Nicholas A.²^ORCID,Levine Nicole L.³,Lazarides Alexander L.⁴^ORCID,Evans Daniel R.¹^ORCID,Spasojevic Ivan⁵⁶,Fan Ping⁵,Jung Sin-Ho⁷,Gao Junheng⁷,Visgauss Julia D.³⁶,Brigman Brian E.³⁶,Eward William C.³⁶

Affiliation:

1. Duke University School of Medicine, Durham, North Carolina, USA

2. Department of Infectious Diseases, Duke University Hospital, Durham, North Carolina, USA

3. Department of Orthopedic Surgery, Duke University Hospital, Durham, North Carolina, USA

4. Department of Sarcoma, Moffitt Cancer Center, Tampa, Florida, USA

5. PK/PD Core Laboratory, Duke University Hospital, Durham, North Carolina, USA

6. Duke Cancer Institute, Duke University Hospital, Durham, North Carolina, USA

7. Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

In orthopedic oncology, the implant of a megaprosthetic device is standard of care after large-scale tumor resection involving segmental removal of bone. Infection remains the leading cause of implant failure, often resulting in major morbidity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00140-22

Reference27 articles.

1. Late Complications and Survival of Endoprosthetic Reconstruction after Resection of Bone Tumors

2. Failure Mode Classification for Tumor Endoprostheses: Retrospective Review of Five Institutions and a Literature Review

3. The Influence of the Alloy of Megaprostheses on Infection Rate

4. Infected Tumor Prostheses

5. PERIPROSTHETIC INFECTION IN PATIENTS TREATED FOR AN ORTHOPAEDIC ONCOLOGICAL CONDITION

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