Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis-Reference-Cited by-同舟云学术

Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis

Published:2020-07-22 Issue:8 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gunesch Antonia P.¹²³^ORCID,Zapatero-Belinchón Francisco J.¹²³,Pinkert Lukas⁴,Steinmann Eike⁵,Manns Michael P.¹²,Schneider Gisbert⁶,Pietschmann Thomas²³^ORCID,Brönstrup Mark²⁴^ORCID,von Hahn Thomas¹²³⁷

Affiliation:

1. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

2. German Center for Infection Research, Hannover-Braunschweig Site, Braunschweig, Germany

3. Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hannover, Germany

4. Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

5. Department for Molecular and Medical Virology, Ruhr Universität Bochum, Bochum, Germany

6. Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Eidgenössische Technische Hochschule, Zurich, Switzerland

7. Department of Gastroenterology and Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Hamburg, Germany

Abstract

Several cationic amphiphilic drugs (CADs) have been found to inhibit cell entry of filoviruses and other enveloped viruses. Structurally unrelated CADs may have antiviral activity, yet the underlying common mechanism and structure-activity relationship are incompletely understood. We aimed to understand how widespread antiviral activity is among CADs and which structural and physico-chemical properties are linked to entry inhibition. We measured inhibition of Marburg virus pseudoparticle (MARVpp) cell entry by 45 heterogeneous and mostly FDA-approved CADs and cytotoxicity in EA.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00143-20

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