Affiliation:
1. Department of Microbiology, The University of Chicago, Chicago, Illinois 60637
Abstract
A series of mutations of
Bacillus subtilis
, conferring sensitivity to methyl methanesulfonate (MMS), were transferred by transformation to a suppressible
his
−
stock. The introduction of certain sensitivity mutations prevented the ultraviolet- or MMS-induced, but not the spontaneous, reversion of
his
−
to
his
+
. Not all sensitivity mutations led to this resistance to mutagenesis; a strain with altered deoxyribonucleic acid (DNA) polymerase activity behaved almost normally with respect to its mutagen response, as did an excision-defective, ultraviolet-sensitive strain used as a control. One of the mutagen-stable strains responded to mutagenesis with nitrosomethylguanidine; another appeared stable even to this mutagen. All mutagen-stable strains had DNA polymerase and DNA ligase activity.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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