Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target-Reference-Cited by-同舟云学术

Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dickie Emily A.¹,Ronin Céline²,Sá Mónica³⁴,Ciesielski Fabrice²,Trouche Nathalie²,Tavares Joana³⁴^ORCID,Santarem Nuno³⁴,Major Louise L.¹,Pemberton Iain K.⁵,MacDougall Jane⁵,Smith Terry K.¹^ORCID,Cordeiro-da-Silva Anabela³⁴⁶,Ciapetti Paola²

Affiliation:

1. Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife, Scotland, United Kingdom

2. NovAliX, Biology Department, Illkirch Cedex, France

3. i3S–Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

4. IBMC-Instituto de Biologia Molecular e Celular, Parasite Disease Group, Porto, Portugal

5. Photeomix Protein Discovery, IP Research Consulting, Noisy Le Grand, France

6. Departmento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal

Abstract

Neglected tropical diseases caused by kinetoplastid parasites ( Trypanosoma brucei , Trypanosoma cruzi , and Leishmania spp.) place a significant health and economic burden on developing nations worldwide. Current therapies are largely outdated, inadequate, and face mounting drug resistance from the causative parasites.

Funder

MEC | Fundação para a Ciência e a Tecnologia

European Community Seventh Framework

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01892-20

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3. World Health Organization. 2020. Leishmaniasis. World Health Organization Geneva Switzerland. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis. Accessed 6 August 2020.

4. DNDi. 2019. Visceral leishmaniasis. DNDi Geneva Switzerland. https://dndi.org/diseases/visceral-leishmaniasis. Accessed 6 August 2020.

5. DNDi. 2020. R&D portfolio. DNDi Geneva Switzerland. https://dndi.org/research-development/portfolio. Accessed 6 August 2020.

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