Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling-Reference-Cited by-同舟云学术

Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling

Published:2022-04-19 Issue:4 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jarugula Praneeth¹,Akcan-Arikan Ayse²³,Munoz-Rivas Flor²,Moffett Brady S.³^ORCID,Ivaturi Vijay¹^ORCID,Rios Danielle⁴

Affiliation:

1. Center for Translational Medicine, Department of Pharmacy Practice and Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA

2. Baylor College of Medicine, Houston, Texas, USA

3. Texas Children’s Hospital, The Woodlands, Texas, USA

4. University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA

Abstract

We determined optimal vancomycin starting dose regimens in infants ≤180 days of age to achieve the highest probability of target attainment with an area under the concentration-time curve for 24 h (AUC 24 ) of ≥400 using population pharmacokinetic (PK) modeling. Secondarily, determination of the relationship between serum creatinine (SCR) and vancomycin clearance in neonates was done.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01899-21

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