Evaluation of the Ultrasensitive Human Immunodeficiency Virus Type 1 (HIV-1) p24 Antigen Assay Performed on Dried Blood Spots for Diagnosis of HIV-1 Infection in Infants-Reference-Cited by-同舟云学术

Evaluation of the Ultrasensitive Human Immunodeficiency Virus Type 1 (HIV-1) p24 Antigen Assay Performed on Dried Blood Spots for Diagnosis of HIV-1 Infection in Infants

Published:2008-02 Issue:2 Volume:15 Page:388-391
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Patton Janet C.¹²³⁴,Coovadia Ashraf H.¹²³⁴,Meyers Tammy M.¹²³⁴,Sherman Gayle G.¹²³⁴

Affiliation:

1. Wits Pediatric HIV Clinics, Wits Health Consortium

2. Departments of Molecular Medicine and Hematology

3. Pediatrics, University of the Witwatersrand

4. National Health Laboratory Service, Johannesburg, South Africa

Abstract

ABSTRACT The diagnostic accuracy of the modified p24 antigen assay performed on pediatric dried blood spots was evaluated. Samples analyzed within 6 weeks of collection yielded no false-positive results (specificity, 100%) and few false-negative results (sensitivity, 96.5% to 98.3%). Laboratory services with limited resources should assess this option for routine infant diagnosis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00265-07

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