Multicenter Clinical Evaluation of a Novel Multiplex Real-Time PCR (qPCR) Assay for Detection of Fluoroquinolone Resistance in Mycoplasma genitalium-Reference-Cited by-同舟云学术

Multicenter Clinical Evaluation of a Novel Multiplex Real-Time PCR (qPCR) Assay for Detection of Fluoroquinolone Resistance in Mycoplasma genitalium

Published:2019-11 Issue:11 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Fernández-Huerta Miguel¹,Bodiyabadu Kaveesha²³⁴,Esperalba Juliana¹,Bradshaw Catriona S.⁵⁶,Serra-Pladevall Judit¹,Garland Suzanne M.³⁴⁷,Fernández-Naval Candela¹,Jensen Jorgen S.⁸^ORCID,Pumarola Tomàs¹,Ebeyan Samantha²,Lundgren Marie²,Tan Lit Yeen²,Espasa Mateu¹⁹^ORCID,Murray Gerald L.³⁴⁷

Affiliation:

1. Microbiology Department, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain

2. SpeeDx Pty Ltd, Sydney, Australia

3. Centre for Women’s Infectious Diseases, The Royal Women’s Hospital, Parkville, Victoria, Australia

4. Murdoch Children’s Research Institute, Parkville, Victoria, Australia

5. Central Clinical School, Monash University, Melbourne, Australia

6. Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia

7. Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia

8. Statens Serum Institut, Copenhagen, Denmark

9. Microbiology Department, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Barcelona, Spain

Abstract

Mycoplasma genitalium causes a common sexually transmitted infection with a marked propensity to develop antimicrobial resistance. As few treatment options exist, this poses significant challenges to clinicians. Recent diagnostic advances have resulted in tests that report the simultaneous detection of M. genitalium and any resistance to macrolides, the first-line treatment. This allows for therapy to be tailored to the individual, thereby optimizing treatment outcomes.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00886-19

Reference20 articles.

1. Mycoplasma genitaliumInfection and Female Reproductive Tract Disease: A Meta-analysis

2. Mycoplasma genitalium: from Chrysalis to Multicolored Butterfly

3. New Horizons in Mycoplasma genitalium Treatment

4. Remarkable increase in fluoroquinolone-resistant Mycoplasma genitalium in Japan

5. Outcomes of Resistance-guided Sequential Treatment ofMycoplasma genitaliumInfections: A Prospective Evaluation

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