NrnA Is a Linear Dinucleotide Phosphodiesterase with Limited Function in Cyclic Dinucleotide Metabolism in Listeria monocytogenes-Reference-Cited by-同舟云学术

NrnA Is a Linear Dinucleotide Phosphodiesterase with Limited Function in Cyclic Dinucleotide Metabolism in Listeria monocytogenes

Published:2022-01-18 Issue:1 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Gall Aaron R.¹^ORCID,Hsueh Brian Y.²^ORCID,Siletti Cheta¹³^ORCID,Waters Christopher M.²,Huynh TuAnh N.¹^ORCID

Affiliation:

1. Food Science Department, University of Wisconsin—Madison, Madison, Wisconsin, USA

2. Microbiology and Molecular Genetics, Michigan State University, Lansing, Michigan, USA

3. Microbiology Doctoral Training Program, University of Wisconsin—Madison, Madison, Wisconsin, USA

Abstract

Listeria monocytogenes produces both c-di-AMP and c-di-GMP and encodes specific phosphodiesterases that degrade them into pApA and pGpG, respectively, but the metabolism of these products has not been characterized in this bacterium. We found that L. monocytogenes NrnA degrades a broad range of nucleotides.

Funder

USDA Hatch Act Formula fund

Wisconsin Dairy Innovation Hub

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00206-21

Reference53 articles.

1. The ever-expanding world of bacterial cyclic oligonucleotide second messengers