Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications-Reference-Cited by-同舟云学术

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

Published:2009-06 Issue:11 Volume:83 Page:5574-5580
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Barde Isabelle¹²,Laurenti Elisa¹,Verp Sonia¹²,Groner Anna Claire¹²,Towne Christopher¹,Padrun Viviane¹,Aebischer Patrick¹,Trumpp Andreas¹,Trono Didier¹²

Affiliation:

1. School of Life Sciences

2. “Frontiers in Genetics” National Center for Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

Abstract

ABSTRACT KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00001-09

Reference35 articles.

1. Ayyanathan, K., M. S. Lechner, P. Bell, G. G. Maul, D. C. Schultz, Y. Yamada, K. Tanaka, K. Torigoe, and F. J. Rauscher III. 2003. Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes Dev.17:1855-1869.

2. Bornkamm, G. W., C. Berens, C. Kuklik-Roos, J. M. Bechet, G. Laux, J. Bachl, M. Korndoerfer, M. Schlee, M. Holzel, A. Malamoussi, R. D. Chapman, F. Nimmerjahn, J. Mautner, W. Hillen, H. Bujard, and J. Feuillard. 2005. Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res.33:e137.

3. Cudre-Mauroux, C., T. Occhiodoro, S. Konig, P. Salmon, L. Bernheim, and D. Trono. 2003. Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a Duchenne myoblast cell line with long-term genotypic and phenotypic stability. Hum. Gene Ther.14:1525-1533.

4. Tetracycline-reversible silencing of eukaryotic promoters.

5. Friedman, J. R., W. J. Fredericks, D. E. Jensen, D. W. Speicher, X. P. Huang, E. G. Neilson, and F. J. Rauscher III. 1996. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev.10:2067-2078.

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