Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment

Author:

Russell Tiffany1,Samolej Jerzy1,Hollinshead Michael2,Smith Geoffrey L.2,Kite Joanne1,Elliott Gillian1ORCID

Affiliation:

1. Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom

2. Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Abstract

Cellular transport pathways play a fundamental role in secretion and membrane biogenesis. Enveloped viruses exploit these pathways to direct their membrane proteins to sites of envelopment and, as such, are powerful tools for unraveling subtle activities of trafficking factors, potentially pinpointing therapeutic targets.

Funder

UKRI | Medical Research Council

British Skin Foundation

Wellcome

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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