Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation

Author:

He Wei1,Yu Gangjin2,Li Tianpeng1,Bai Ling1,Yang Yuanyuan1,Xue Zixiao13,Pang Yonghao1,Reichmann Dana3,Hiller Sebastian4,He Lichun25,Liu Maili25,Quan Shu1ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB), Shanghai, China

2. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan National Laboratory for Optoelectronics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China

3. Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem, Jerusalem, Israel

4. Biozentrum, University of Basel, Basel, Switzerland

5. University of Chinese Academy of Sciences, Beijing, China

Abstract

Outer membrane proteins (OMPs) play critical roles in bacterial pathogenicity and provide a new niche for antibiotic development. A comprehensive understanding of the OMP quality control network will strongly impact antimicrobial discovery.

Funder

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

MOST | National Key Research and Development Program of China

Swiss National Science Foundation

State Key Laboratory of Bioreactor Engineering

ISF-NSFC Joint Research Program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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