Protospacer-Adjacent Motif Specificity during Clostridioides difficile Type I-B CRISPR-Cas Interference and Adaptation-Reference-Cited by-同舟云学术

Protospacer-Adjacent Motif Specificity during Clostridioides difficile Type I-B CRISPR-Cas Interference and Adaptation

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Maikova Anna¹²³^ORCID,Boudry Pierre²,Shiriaeva Anna¹³,Vasileva Aleksandra⁴,Boutserin Anaïs²,Medvedeva Sofia¹,Semenova Ekaterina⁵,Severinov Konstantin¹⁵⁶,Soutourina Olga²⁷^ORCID

Affiliation:

1. Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia

2. Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

3. Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia

4. Institute of Gene Biology, Centre for Precision Genome Editing and Genetic Technologies for Biomedicine, Russian Academy of Sciences, Moscow, Russia

5. Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA

6. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

7. Institut Universitaire de France (IUF), Paris, France

Abstract

CRISPR-Cas systems provide prokaryotes with adaptive immunity for defense against foreign nucleic acid invaders, such as viruses or phages and plasmids. The CRISPR-Cas systems are highly diverse, and detailed studies of individual CRISPR-Cas subtypes are important for our understanding of various aspects of microbial adaptation strategies and for the potential applications.

Funder

Agence Nationale de la Recherche

Institut Universitaire de France

Université Paris-Saclay

Institute for Integrative Biology of the Cell

DIM-1HEALTH

CNRS-RFBR

HHS | National Institutes of Health

Skolkovo Institute of Science and Technology

Vernadski fellowship

Publisher

American Society for Microbiology