The Polar Legionella Icm/Dot T4SS Establishes Distinct Contact Sites with the Pathogen Vacuole Membrane

Author:

Böck Désirée1,Hüsler Dario2,Steiner Bernhard2,Medeiros João M.1,Welin Amanda2,Radomska Katarzyna A.1,Hardt Wolf-Dietrich3,Pilhofer Martin1,Hilbi Hubert2ORCID

Affiliation:

1. Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland

2. Institute of Medical Microbiology, Faculty of Medicine, University of Zürich, Zürich, Switzerland

3. Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland

Abstract

Legionnaires’ disease is a life-threatening pneumonia, which is characterized by high fever, coughing, shortness of breath, muscle pains, and headaches. The disease is caused by the amoeba-resistant bacterium L. pneumophila found in various soil and aquatic environments and is transmitted to humans via the inhalation of small bacteria-containing droplets.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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