Pseudomonas aeruginosa Production of Hydrogen Cyanide Leads to Airborne Control of Staphylococcus aureus Growth in Biofilm and <i>In Vivo</i> Lung Environments-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa Production of Hydrogen Cyanide Leads to Airborne Control of Staphylococcus aureus Growth in Biofilm and In Vivo Lung Environments

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Létoffé Sylvie¹,Wu Yongzheng²,Darch Sophie E.³^ORCID,Beloin Christophe¹^ORCID,Whiteley Marvin⁴^ORCID,Touqui Lhousseine⁵⁶,Ghigo Jean-Marc¹^ORCID

Affiliation:

1. Institut Pasteur, Université de Paris Cité, CNRS UMR 6047, Genetics of Biofilms Laboratory, Paris, France

2. Institut Pasteur, Université de Paris Cité, CNRS UMR3691, Cellular Biology of Microbial Infection Laboratory, Paris, France

3. Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA

4. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA

5. Institut Pasteur, Université de Paris Cité, Mucoviscidose et Bronchopathies Chroniques, Paris, France

6. Centre de Recherche Saint-Antoine, Sorbonne Université, Inserm, Paris, France

Abstract

Airborne volatile compounds produced by bacteria are often only considered attractive or repulsive scents, but they also directly contribute to bacterial physiology. Here, we showed that volatile hydrogen cyanide (HCN) released by a wide range of Pseudomonas aeruginosa strains controls Staphylococcus aureus growth in low-oxygen in vitro biofilms or aggregates and in vivo lung environments.

Funder

Labex IBEID Integrative Biology of Emerging Infectious Diseases

Fondation pour la Recherche Médicale

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02154-22

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