The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus-Reference-Cited by-同舟云学术

The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Nacken Wolfgang¹²,Schreiber André¹²,Masemann Dörthe¹²³,Ludwig Stephan¹²³^ORCID

Affiliation:

1. Institute of Virology (IVM), University of Muenster, Muenster, Germany

2. University Hospital Muenster, Muenster, Germany

3. Interdisciplinary Center of Clinical Research (IZKF), Medical Faculty of Westfaelische Wilhelms University of Muenster, Muenster, Germany

Abstract

We investigated the role of IAV nonstructural protein 1 NS1 in host gene shutoff—a central feature of IAV replication. We demonstrate that the effector domain of NS1 alone mediates host gene shutoff by inhibition of host transcription and by deregulation of the polyadenylation (polyA) signal-mediated 3′ termination of host transcription.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02196-21

Reference36 articles.

1. Suppression of the antiviral response by an influenza histone mimic

2. The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

3. The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection