Integrative Activity of Mating Loci, Environmentally Responsive Genes, and Secondary Metabolism Pathways during Sexual Development of Chaetomium globosum

Author:

Wang Zheng1,López-Giráldez Francesc23,Wang Junrui1,Trail Frances4,Townsend Jeffrey P.156ORCID

Affiliation:

1. Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA

2. Yale Center for Genome Analysis, Yale University, New Haven, Connecticut, USA

3. Department of Genetics, Yale University, New Haven, Connecticut, USA

4. Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan, USA

5. Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA

6. Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA

Abstract

Fungal diversity has amazed evolutionary biologists for decades. One societally important aspect of this diversity manifests in traits that enable pathogenicity. The opportunistic pathogen Chaetomium globosum is well adapted to a high-humidity environment and produces numerous secondary metabolites that defend it from predation. Many of these chemicals can threaten human health. Understanding the phases of the C. globosum life cycle in which these products are made enables better control and even utilization of this fungus. Among its intriguing traits is that it both is self-fertile and lacks any means of propagule-based asexual reproduction. By profiling genome-wide gene expression across the process of sexual reproduction in C. globosum and comparing it to genome-wide gene expression in the model filamentous fungus N. crassa and other closely related fungi, we revealed associations among mating-type genes, sexual developmental genes, sexual incompatibility regulators, environmentally responsive genes, and secondary metabolic pathways.

Funder

Michigan AgBioresearch

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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