Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis

Author:

Gerner Romana R.1ORCID,Hossain Suzana1,Sargun Artur2,Siada Kareem1,Norton Grant J.1,Zheng Tengfei2,Neumann Wilma2,Nuccio Sean-Paul1ORCID,Nolan Elizabeth M.2ORCID,Raffatellu Manuela134ORCID

Affiliation:

1. Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA

2. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

3. Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA

4. Chiba University-University of California-San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, California, USA

Abstract

Adherent-invasive Escherichia coli (AIEC) is abnormally prevalent in patients with ileal Crohn’s disease and exacerbates intestinal inflammation, but treatment strategies that selectively target AIEC are unavailable. Iron is an essential micronutrient for most living organisms, and bacterial pathogens have evolved sophisticated strategies to capture iron from the host environment.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Burroughs Wellcome Fund

Crohn's and Colitis Foundation

Max Kade Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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