Uptake of the Siderophore Triacetylfusarinine C, but Not Fusarinine C, Is Crucial for Virulence of Aspergillus fumigatus

Author:

Aguiar Mario1,Orasch Thomas1,Shadkchan Yana2,Caballero Patricia1,Pfister Joachim3,Sastré-Velásquez Luis Enrique1,Gsaller Fabio1,Decristoforo Clemens3,Osherov Nir2,Haas Hubertus1ORCID

Affiliation:

1. Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria

2. Department of Clinical Microbiology and Immunology, Sackler School of Medicine Ramat-Aviv, Tel Aviv, Israel

3. Department of Nuclear Medicine, Medical University Innsbruck, Innsbruck, Austria

Abstract

Aspergillus fumigatus is responsible for thousands of cases of invasive fungal disease annually. For iron uptake, A. fumigatus secretes so-called siderophores, which are taken up after the binding of environmental iron.

Funder

Austrian Science Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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