High-Throughput CRISPR Screens To Dissect Macrophage- Shigella Interactions-Reference-Cited by-同舟云学术

High-Throughput CRISPR Screens To Dissect Macrophage- Shigella Interactions

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lai Yong¹²³,Cui Liang¹,Babunovic Gregory H.⁴,Fortune Sarah M.⁴⁵,Doench John G.⁶,Lu Timothy K.¹²³⁶⁷^ORCID

Affiliation:

1. Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore

2. Synthetic Biology Group, MIT Synthetic Biology Center, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA

3. Research Laboratory of Electronics, MIT, Cambridge, Massachusetts, USA

4. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

5. Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA

6. Broad Institute, Cambridge, Massachusetts, USA

7. Department of Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, USA

Abstract

Treatment for shigellosis is becoming increasingly difficult as resistance to antibiotics becomes more prevalent. One way to prevent this significant public health problem from developing into a full-blown crisis is to approach shigellosis intervention from the point of view of the host.

Funder

The United States Defense Threat Reduction Agency

The National Research Foundation, Singapore

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02158-21

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