Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey

Author:

Mathema Barun1ORCID,Chen Liang23ORCID,Wang Pengfei4,Cunningham Marcus H.2,Mediavilla Jose R.2,Chow Kar Fai5,Luo Yang4,Zhao Yanan23ORCID,Composto Kaelea2,Zuckerman Jerry6,Zody Michael C.7,Wilson Nancy8,Lee Annie2,Oschwald Dayna M.7,Liu Lihong4,Iketani Sho9,Germer Soren7,Fennessey Samantha7,Wang Maple4,Kramer Yael5,Toole Patricia8,Maniatis Tom7,Ho David D.4910,Perlin David S.23ORCID,Kreiswirth Barry N.2ORCID

Affiliation:

1. Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York, USA

2. Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA

3. Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

4. Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

5. Hackensack Meridian Health Biorepository, Hackensack, New Jersey, USA

6. Hackensack University Medical Center, Hackensack, New Jersey, USA

7. New York Genome Center, New York, New York, USA

8. Hackensack Meridian Health, Carrier Clinic, Belle Mead, New Jersey, USA

9. Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA

10. Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

Abstract

The neutralizing capacities of monoclonal antibodies used to treat COVID-19 and of those recovered from previously infected and vaccinated individuals against SARS-CoV-2 variants of concern (VOCs) remain important questions. We report on a nosocomial outbreak caused by a SARS-CoV-2 R.1 variant harboring an E484K mutation among 81 unvaccinated inpatients and health care professionals.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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