A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells-Reference-Cited by-同舟云学术

A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Knuschke Torben¹^ORCID,Kollenda Sebastian²³,Wenzek Christina¹,Zelinskyy Gennadiy⁴,Steinbach Philine¹,Dittmer Ulf⁴,Buer Jan¹,Epple Matthias²³,Westendorf Astrid M.¹

Affiliation:

1. Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

2. Institute of Inorganic Chemistry, Essen, Germany

3. Centre for Nanointegration Duisburg-Essen (CeNIDE), Essen, Germany

4. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Abstract

Despite significant efforts, vaccines are not yet available for every infectious pathogen, and the search for a protective approach to prevent the establishment of chronic infections, i.e., with HIV, continues. Immune checkpoint therapies targeting inhibitory receptors, such as PD-1, have shown impressive results against solid tumors.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02121-20

Reference56 articles.

1. T cells and viral persistence: lessons from diverse infections

2. Overcoming T cell exhaustion in infection and cancer

3. Restoring function in exhausted CD8 T cells during chronic viral infection