Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women-Reference-Cited by-同舟云学术

Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Day Christopher J.¹,Hardison Rachael L.²,Spillings Belinda L.¹,Poole Jessica¹,Jurcisek Joseph A.²,Mak Johnson¹,Jennings Michael P.¹^ORCID,Edwards Jennifer L.²³^ORCID

Affiliation:

1. Institute for Glycomics, Griffith University, Southport, Queensland, Australia

2. Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

3. Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA

Abstract

In women, the lower female reproductive tract is the primary site for HIV infection. How HIV traverses the epithelium to infect CD4 T cells in the submucosa is ill-defined.

Funder

Australian Centre for HIV and Hepatitis Virology Research

HHS | National Institutes of Health

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02177-21

Reference126 articles.

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2. Centers for Disease Control and Prevention. 2013. CDC fact sheet—HIV among women. https://www.cdc.gov/hiv/pdf/group/gender/women/cdc-hiv-women.pdf.

3. World Health Organization. 2021. Global summary of AIDS epidemic Global Health Observatory (GHO) data. https://www.who.int/data/gho/data/themes/hiv-aids.

4. Current concepts of HIV transmission

5. Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

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