Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity-Reference-Cited by-同舟云学术

Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity

Published:2021-06-24 Issue:14 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Resnick Samuel J.¹²,Iketani Sho³⁴,Hong Seo Jung¹,Zask Arie⁵,Liu Hengrui⁶,Kim Sungsoo¹,Melore Schuyler¹,Lin Fang-Yu⁷,Nair Manoj S.³,Huang Yaoxing³,Lee Sumin⁶,Tay Nicholas E. S.⁶,Rovis Tomislav⁶,Yang Hee Won¹,Xing Li⁷,Stockwell Brent R.⁵⁶,Ho David D.³,Chavez Alejandro¹^ORCID

Affiliation:

1. Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA

2. Medical Scientist Training Program, Columbia University Irving Medical Center, New York, New York, USA

3. Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, New York, USA

4. Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA

5. Department of Biological Sciences, Columbia University, New York, New York, USA

6. Department of Chemistry, Columbia University, New York, New York, USA

7. WuXi AppTec, Cambridge, Massachusetts, USA

Abstract

Multiple coronavirus pandemics have occurred over the last 2 decades. This has highlighted a need to be proactive in the development of therapeutics that can be readily deployed in the case of future coronavirus pandemics.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02374-20

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