MRSA Isolates from Patients with Persistent Bacteremia Generate Nonstable Small Colony Variants In Vitro within Macrophages and Endothelial Cells during Prolonged Vancomycin Exposure

Author:

Fauerharmel-Nunes Thiago1,Flannagan Ronald S.1ORCID,Goncheva Mariya I.1ORCID,Bayer Arnold S.234,Fowler Vance G.5,Chan Liana C.2346,Yeaman Michael R.2346,Xiong Yan Q.234,Heinrichs David E.1ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada

2. The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA

3. David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

4. Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA

5. Duke University Medical Center, Durham, North Carolina, USA

6. Division of Molecular Medicine, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA

Abstract

Staphylococcus aureus (especially methicillin-resistant S. aureus [MRSA]) is frequently associated with persistent bacteremia (PB) during vancomycin therapy despite consistent susceptibility in vitro . Strategic comparisons of PB strains versus those from vancomycin-resolving bacteremia (RB) would yield important mechanistic insights into PB outcomes.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3