Aspergillus Lateral Flow Assay with Digital Reader for the Diagnosis of COVID-19-Associated Pulmonary Aspergillosis (CAPA): a Multicenter Study

Author:

Autier Brice1ORCID,Prattes Juergen2,White P. Lewis3ORCID,Valerio Maricela45,Machado Marina45,Price Jessica3,Egger Matthias2,Gangneux Jean-Pierre1ORCID,Hoenigl Martin267ORCID

Affiliation:

1. Université de Rennes, CHU Rennes, INSERM, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France

2. Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria

3. Public Health Wales Mycology Reference Laboratory, UHW, Cardiff, UK

4. Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain

5. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

6. Clinical and Translational Fungal-Working Group, University of California San Diego, San Diego, California, USA

7. Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California, USA

Abstract

This multicenter study evaluated the IMMY Aspergillus Galactomannan Lateral Flow Assay (LFA) with automated reader for diagnosis of pulmonary aspergillosis in patients with COVID-19-associated acute respiratory failure (ARF) requiring intensive care unit (ICU) admission between 03/2020 and 04/2021. A total of 196 respiratory samples and 148 serum samples ( n  = 344) from 238 patients were retrospectively included, with a maximum of one of each sample type per patient.

Funder

IMMY Diagnostics

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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