Enhanced<i>In Vitro</i>and<i>In Vivo</i>Potency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions-Reference-Cited by-同舟云学术

EnhancedIn VitroandIn VivoPotency of a T Cell Epitope in the Ebola Virus Glycoprotein Following Amino Acid Replacement at HLA-A*02:01 Binding Positions

Published:2022-09-28 Issue:18 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chabot Sylvie¹,Gimie Yusra¹,Obeid Karam¹,Kim Jaekwan¹,Meseda Clement A.¹,Konduru Krishnamurthy²,Kaplan Gerardo²,Sheng Fowler Li¹,Weir Jerry P.¹,Peden Keith¹,Major Marian E.¹^ORCID

Affiliation:

1. Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

2. Division of Emerging Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA

Abstract

Vaccine efficacy and immunity to viral infection are often measured by neutralizing antibody titers. T cells are specialized subsets of immune cells with antiviral activity, but this response is variable and difficult to track.

Funder

HHS | U.S. Food and Drug Administration

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01166-21

Reference52 articles.

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2. Mice Antibody Response to Conserved Nonadjuvanted Multiple Antigenic Peptides Derived from E1/E2 Regions of Hepatitis C Virus

3. Centers for Disease Control and Prevention C. 2021. History of Ebola virus disease (EVD) outbreaks. https://www.cdc.gov/vhf/ebola/history/chronology.html. Accessed August 29 2022.

4. U.S. Food and Drug Administration. December 19 2019. First FDA-approved vaccine for the prevention of Ebola virus disease marking a critical milestone in public health preparedness and response. https://www.fda.gov/news-events/press-announcements/first-fda-approved-vaccine-prevention-ebola-virus-disease-marking-critical-milestone-public-health. Accessed August 29 2022.

5. World Health Organization. 2021. Ebola virus disease. https://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease. Accessed August 29 2022.

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