Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito-Reference-Cited by-同舟云学术

Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito

Published:2020-10-14 Issue:21 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Liu Ke¹,Xiao Changguang¹,Xi Shumin¹,Hameed Muddassar¹,Wahaab Abdul¹,Shao Donghua¹,Li Zongjie¹,Li Beibei¹,Wei Jianchao¹,Qiu Yafeng¹,Miao Denian²,Zhu Huaimin³,Ma Zhiyong¹^ORCID

Affiliation:

1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People’s Republic of China

2. Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai, People’s Republic of China

3. Department of Pathogen Biology, Second Military Medical University, Shanghai, People’s Republic of China

Abstract

In this study, we observed the complex roles of mosquito defensin in JEV infection; mosquito defensin exhibited a weak antiviral effect but strongly enhanced binding. In the latter, defensin directly binds the ED III domain of the viral E protein and promotes the adsorption of JEV to target cells by interacting with lipoprotein receptor-related protein 2 (LRP2), thus accelerating virus entry. Together, our results indicate that mosquito defensin plays an important role in facilitating JEV infection and potential transmission.

Funder

National Key Research and Development Program of China

Applied research on disease prevention and controls in military

Natural Science Foundation of Shanghai

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01164-20

Reference44 articles.

1. Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus