Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux-Reference-Cited by-同舟云学术

Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux

Published:1994-10 Issue:10 Volume:38 Page:2492-2494
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Leonard P J¹,Rathod P K¹,Golin J¹

Affiliation:

1. Department of Biology, Catholic University of America, Washington, D.C. 20064.

Abstract

The yeast (Saccharomyces cerevisiae) PDR5 gene product encodes a 160-kDa protein related to the large ABC family of transporters, including the human MDR1 multidrug resistance p-glycoprotein. Loss of function mutations in PDR5 result in chloramphenicol hypersensitivity. A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDR5 (wild-type) control.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.10.2492

Reference9 articles.

1. Balzi E. and A. Goffeau. Genetics and biochemistry of yeast multidrug resistance. Biochim. Biophys. Acta in press.

2. PDRS, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1;Balzi E.;J. Biol. Chem.,1994

3. Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5;Dexter D.;Genetics,1994

4. Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines;Fojo A.;Cancer Res.,1985

5. Several alleles of the multidrug resistant genes are closely linked to chloroquine resistance in Plasmodium falciparum;Foote S. J.;Nature (London),1990

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