Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis-Reference-Cited by-同舟云学术

Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Stott Katharine E.¹²^ORCID,Beardsley Justin³,Kolamunnage-Dona Ruwanthi⁴,Castelazo Anahi Santoyo¹,Kibengo Freddie Mukasa⁵,Mai Nguyen Thi Hoang⁶,Tùng Nguyễn Lê Nhu’⁶,Cuc Ngo Thi Kim⁶,Day Jeremy³⁷,Hope William¹^ORCID

Affiliation:

1. Antimicrobial Pharmacodynamics and Therapeutics Laboratory, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

2. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

3. Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

4. Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

5. MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda

6. Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

7. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Abstract

Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the central nervous system (CNS) is not known.

Funder

Wellcome Trust

European and Developing Countries Clinical Trials Partnership

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00885-18

Reference42 articles.

1. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

2. Combination Antifungal Therapy for Cryptococcal Meningitis