Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases-Reference-Cited by-同舟云学术

Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chatwin Cassandra L.¹,Hamrick Jodie C.¹,Trout Robert E. L.¹,Myers Cullen L.¹,Cusick Susan M.¹,Weiss William J.²,Pulse Mark E.²,Xerri Luigi¹,Burns Christopher J.¹,Moeck Gregory¹,Daigle Denis M.¹^ORCID,John Kaitlyn³,Uehara Tsuyoshi¹,Pevear Daniel C.¹

Affiliation:

1. Venatorx Pharmaceuticals, Incorporated, Malvern, Pennsylvania, USA

2. UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, USA

3. MTF Biologics, Edison, New Jersey, USA

Abstract

There is an urgent need for oral agents to combat resistant Gram-negative pathogens. Here, we describe the characterization of VNRX-5236, a broad-spectrum boronic acid β-lactamase inhibitor (BLI), and its orally bioavailable etzadroxil prodrug, VNRX-7145.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00552-21

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