Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1-Reference-Cited by-同舟云学术

Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vollmer Kathryn J.¹,Burns Anna C.¹,Sauer Hannah E.¹,Williams John D.²,Komazin-Meredith Gloria²,Cardinale Steve²,Butler Michelle²,Aron Zachary²,Hussein Islam²,Busch Marc G.³,Bowlin Terry L.²,Gentry Brian G.¹

Affiliation:

1. Department of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa, USA

2. Microbiotix Inc., Worcester, Massachusetts, USA

3. Department of Biology, College of Arts and Sciences, Drake University, Des Moines, Iowa, USA

Abstract

To determine the mechanism of action of third-generation methylenecyclopropane nucleoside analogs (MCPNAs), DNA sequencing of herpes simplex virus 1 (HSV-1) isolates resistant to third-generation MCPNAs resulted in the discovery of G841S and N815S mutations in HSV-1 UL30.

Funder

HHS | National Institutes of Health

Iowa Space Grant Consortium

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01301-19

Reference34 articles.

1. Tools for the Diagnosis of Herpes Simplex Virus 1/2: Systematic Review of Studies Published Between 2012 and 2018

2. Clinical Features of Varicella-Zoster Virus Infection