Antiretroviral Therapy with a Twice-Daily Regimen Containing 400 Milligrams of Indinavir and 100 Milligrams of Ritonavir in Human Immunodeficiency Virus Type 1-Infected Women during Pregnancy-Reference-Cited by-同舟云学术

Antiretroviral Therapy with a Twice-Daily Regimen Containing 400 Milligrams of Indinavir and 100 Milligrams of Ritonavir in Human Immunodeficiency Virus Type 1-Infected Women during Pregnancy

Published:2008-04 Issue:4 Volume:52 Page:1542-1544
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ghosn Jade¹,De Montgolfier Ines²,Cornélie Chantal³,Dominguez Stéphanie¹,Pérot Claire²,Peytavin Gilles⁴,Marcelin Anne-Geneviève⁵,Pauchard Michèle¹,Ouagari Zineb¹,Bonmarchand Manuela⁶,Agher Rachid¹,Calvez Vincent⁵,Bricaire François¹,Dommergues Marc³,Katlama Christine¹,Tubiana Roland¹

Affiliation:

1. AP-HP, Department of Infectious Diseases, Pitié-Salpétrière Hospital, Paris, France

2. AP-HP, Department of Neonatology, Pitié-Salpétrière Hospital, Paris, France

3. AP-HP, Department of Gynecology and Obstetrics, Pitié-Salpétrière Hospital, Paris, France

4. AP-HP, Department of Clinical Pharmacology, Bichat-Claude Bernard Hospital, Paris, France

5. AP-HP, Department of Virology, Pitié-Salpétrière Hospital, Paris, France

6. AP-HP, Department of Internal Medicine, Pitié-Salpétrière Hospital, Paris, France

Abstract

ABSTRACT We evaluated the safety and efficacy of a twice daily regimen containing 400 mg of indinavir and 100 mg of ritonavir in 32 human immunodeficiency virus (HIV)-infected women during pregnancy. The median indinavir trough concentration was 208 ng/ml during the third trimester. At delivery, 26 of 28 women on indinavir-ritonavir had HIV RNA levels of <200 copies/ml. No infant was HIV infected. These data are encouraging for the use of this combination for prevention of mother-to-child transmission of HIV.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01301-07

Reference18 articles.

1. Burger, D. M., R. M. Hoetelmans, P. W. Hugen, J. W. Mulder, P. L. Meenhorst, P. P. Koopmans, K. Brinkman, M. Keuter, W. Dolmans, and Y. A. Hekster. 1998. Low plasma concentrations of indinavir are related to virological treatment failure in HIV-1-infected patients on indinavir-containing triple therapy. Antivir. Ther.3:215-220.

2. Burger, D. M., P. W. Hugen, R. E. Aarnoutse, J. P. Dieleman, J. M. Prins, T. van der Poll, J. H. ten Veen, J. W. Mulder, P. L. Meenhorst, W. L. Blok, J. T. van der Meer, P. Reiss, and J. M. Lange. 2001. A retrospective, cohort-based survey of patients using twice-daily indinavir + ritonavir combinations: pharmacokinetics, safety, and efficacy. J. Acquir. Immune Defic. Syndr.26:218-224.

3. Cressey, T. R., P. Leenasirimakul, G. Jourdain, M. Tod, P. O. Sukrakanchana, S. Kunkeaw, C. Puttimit, and M. Lallemant. 2005. Low-doses of indinavir boosted with ritonavir in HIV-infected Thai patients: pharmacokinetics, efficacy and tolerability. J. Antimicrob. Chemother.55:1041-1044.

4. Duvivier, C., A. Myrto, A. G. Marcelin, J. Ghosn, H. Ait-Mohand, L. Schneider, R. Agher, F. Bricaire, D. Costagliola, V. Calvez, G. Peytavin, and C. Katlama. 2003. Efficacy and safety of ritonavir/indinavir 100/400 mg twice daily in combination with two nucleoside analogues in antiretroviral treatment-naive HIV-infected individuals. Antivir. Ther.8:603-609.

5. Feiterna-Sperling, C., K. Weizsaecker, C. Buhrer, S. Casteleyn, A. Loui, T. Schmitz, V. Wahn, and M. Obladen. 2007. Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants. J. Acquir. Immune Defic. Syndr.45:43-51.

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Clinical pharmacology of anti-infectives during pregnancy;Clinical Pharmacology During Pregnancy;2022

2. Pharmacokinetic Enhancement of HIV Antiretroviral Therapy During Pregnancy;The Journal of Clinical Pharmacology;2020-08-14

3. Reduced indinavir exposure during pregnancy;British Journal of Clinical Pharmacology;2013-08-20

4. HIV Protease Inhibitors in Pregnancy;Drugs;2013-02-13

5. C linical Pharmacology of Anti-Infectives During Pregnancy;Clinical Pharmacology During Pregnancy;2013