Affiliation:
1. Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal
Abstract
ABSTRACT
Listeria monocytogenes
mutants defective in the
actA
gene, the
plcB
gene, and the
inlA
and
inlB
genes were less virulent when injected intravenously into BALB/c mice. The growth of these strains as well as of the virulent wild-type strains was increased by treating mice with a neutrophil-specific depleting monoclonal antibody, RB6-8C5. Histologic examination of the livers of the treated animals showed intrahepatocytic proliferation of the listeriae in all cases. Our data show that more than one pathway exists that allows
L. monocytogenes
to invade parenchymal cells. One pathway most likely involves the
actA
and
plcB
gene products, and a second one probably involves the internalins.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
9 articles.
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