Two Allelic Forms of the Aureolysin Gene ( aur ) within Staphylococcus aureus

Author:

Sabat Artur1,Kosowska Klaudia1,Poulsen Knud2,Kasprowicz Andrzej3,Sekowska Agnieszka4,van den Burg Bertus5,Travis James6,Potempa Jan16

Affiliation:

1. Department of Microbiology and Immunology, Institute of Molecular Biology, Jagiellonian University, 31-120 Krakow,1 and

2. Department of Medical Microbiology and Immunology, University of Aarhus, DK-8000 Aarhus, Denmark2;

3. Center of Microbiological Research and Autovaccines, 31-016 Krakow,3Poland;

4. Institut Pasteur Unite Regulation de l'Expression Genetique, 75724 Paris, France4;

5. Department of Genetics, Groningen Sciences and Biotechnology Institute, Haren, The Netherlands5; and

6. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 306026

Abstract

ABSTRACT Proteinases of Staphylococcus aureus are emerging as potential virulence factors which may be involved in the pathogenecity of staphylococcal diseases. We describe here the structure of the gene encoding the metalloproteinase referred to as aureolysin. This gene occurs in two allelic forms and is strongly conserved among S. aureus strains, implying the possibility that the proteinase may have important housekeeping functions.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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