Construction of Urease-Negative Mutants of Yersinia enterocolitica Serotypes O:3 and O:8: Role of Urease in Virulence and Arthritogenicity-Reference-Cited by-同舟云学术

Construction of Urease-Negative Mutants of Yersinia enterocolitica Serotypes O:3 and O:8: Role of Urease in Virulence and Arthritogenicity

Published:2000-02 Issue:2 Volume:68 Page:942-947
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Gripenberg-Lerche Christel¹²³⁴,Zhang Lijuan¹²⁵,Ahtonen Päivi¹²⁵,Toivanen Paavo¹²,Skurnik Mikael⁶⁵

Affiliation:

1. Turku Immunology Center1 and

2. Departments of Medical Microbiology,2

3. Medicine,4

4. Turku University, National Public Health Institute,3

5. Turku Center for Biotechnology, Turku University, and Åbo Academy University,5 Turku, Finland

6. Medical Biochemistry,6 and

Abstract

ABSTRACT Yersinia enterocolitica serotype O:3 and O:8 urease-negative mutants unable to express the 19-kDa β subunit of urease were constructed and tested for virulence and arthritogenicity. Our results indicate that urease is needed for full virulence in oral infections and that it is not an arthritogenic factor in the rat model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.2.942-947.2000

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