Comparison of the Roles of Calcineurin in Physiology and Virulence in Serotype D and Serotype A Strains of Cryptococcus neoformans-Reference-Cited by-同舟云学术

Comparison of the Roles of Calcineurin in Physiology and Virulence in Serotype D and Serotype A Strains of Cryptococcus neoformans

Published:2000-02 Issue:2 Volume:68 Page:982-985
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cruz M. Cristina¹,Sia Rey A. L.¹,Olson Michael²,Cox Gary M.³,Heitman Joseph¹²⁴³⁵

Affiliation:

1. Departments of Genetics,1

2. Pharmacology and Cancer Biology,2

3. Medicine,3 and the

4. Microbiology,4 and

5. Howard Hughes Medical Institute,5 Duke University Medical Center, Durham, North Carolina 27710

Abstract

ABSTRACT The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans . Serotype A and serotype D calcineurin mutants were inviable at 37°C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.2.982-985.2000

Reference28 articles.

1. Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains;Breuder T.;Proc. Natl. Acad. Sci. USA,1994

2. Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.

3. Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence

4. Isolation of the Third Capsule-Associated Gene, CAP60 , Required for Virulence in Cryptococcus neoformans

5. The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence

Cited by 72 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transcriptional and Post-Translational Roles of Calcineurin in Cationic Stress and Glycerol Biosynthesis in Cryptococcus neoformans;Journal of Fungi;2024-07-30

2. A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii;Scientific Reports;2022-09-27

3. Gene, virulence and related regulatory mechanisms in <italic>Cryptococcus gattii</italic>;Acta Biochimica et Biophysica Sinica;2022-03-25

4. Development of an efficient gene-targeting system for elucidating infection mechanisms of the fungal pathogen Trichosporon asahii;Scientific Reports;2021-09-14

5. Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance in Cryptococcus neoformans;Genetics;2019-09-01