Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016-Reference-Cited by-同舟云学术

Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016

Published:2017-05 Issue:5 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Novović Katarina¹,Trudić Anika²³,Brkić Snežana⁴,Vasiljević Zorica⁵,Kojić Milan¹,Medić Deana²⁶,Ćirković Ivana⁷,Jovčić Branko¹⁸^ORCID

Affiliation:

1. Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia

2. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

3. Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia

4. Institute for Laboratory Diagnostics Konzilijum, Belgrade, Serbia

5. Department of Clinical Microbiology, Mother and Child Health Care Institute of Serbia Dr. Vukan Cupic, Belgrade, Serbia

6. Institute of Public Health of Vojvodina, Novi Sad, Serbia

7. Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

8. Faculty of Biology, University of Belgrade, Belgrade, Serbia

Abstract

ABSTRACT Twenty-seven colistin-resistant, carbapenemase-producing Klebsiella pneumoniae isolates were identified from hospitals in Serbia. All isolates were bla CTX-M-15 positive; ST101, ST888, ST437, ST336, and ST307 were bla OXA-48 positive; and ST340 was bla NDM-1 positive. ST307 had an insertion, and ST336 had a premature stop codon in the mgrB gene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST307. The mcr-1 and mcr-2 were not detected. An increase in phoP , phoQ , and pmrK gene transcription was detected for all sequence types.

Funder

Ministry of Education, Science and Technological Development of the Republic of Serbia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02550-16

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