qnrE1 , a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species-Reference-Cited by-同舟云学术

qnrE1 , a Member of a New Family of Plasmid-Located Quinolone Resistance Genes, Originated from the Chromosome of Enterobacter Species

Published:2017-05 Issue:5 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Albornoz Ezequiel¹,Tijet Nathalie²,De Belder Denise¹,Gomez Sonia¹,Martino Florencia¹,Corso Alejandra¹,Melano Roberto G.²,Petroni Alejandro¹

Affiliation:

1. Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas–ANLIS “Dr. Carlos G. Malbrán,” Ciudad Autónoma de Buenos Aires, Argentina

2. Public Health Ontario Laboratory, Toronto, Ontario, Canada

Abstract

ABSTRACT qnrE1 , found in a clinical Klebsiella pneumoniae isolate, was undetectable by PCR assays used for the six qnr families. qnrE1 was located on a conjugative plasmid (ca. 185 kb) and differed from qnrB alleles by 25%. Phylogenetic reconstructions of qnr genes and proteins and analysis of the qnrE1 surroundings showed that this gene belongs to a new qnr family and was likely mobilized by IS Ecp1 from the chromosome of Enterobacter spp. to plasmids of K. pneumoniae .

Funder

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02555-16

Reference29 articles.

1. Quinolone resistance from a transferable plasmid

2. Plasmid-mediated quinolone resistance;Jacoby GA;Microbiol Spectr,2014

3. QnrVC, a new transferable Qnr-like family