Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea-Reference-Cited by-同舟云学术

Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea

Published:1997-02 Issue:2 Volume:41 Page:460-464
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Palmer S¹,Cox S¹

Affiliation:

1. Virology Department, Swedish Institute for Infectious Disease Control, Karolinska Institute, Stockholm, Sweden.

Abstract

The intracellular phosphorylation of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine was increased two- to threefold by the addition of hydroxyurea (HU) to the single drugs or to the two drugs in combination. The ratios of drug triphosphate to competing cellular deoxynucleoside triphosphate were increased two- to threefold for both 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of HU. These HU-induced increases in 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine metabolism may further enhance the anti-human immunodeficiency virus activity of these two drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.2.460

Reference46 articles.

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4. Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis;Bianchi V.;J. Biol. Chem.,1986

5. Cellular metabolism of (~)enantiomeric 2~-deoxy-3~-thiacytidine;Cammack N.;Biochem. Pharmacol.,1992

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