Evaluation of the hepatotoxic potential of minocycline-Reference-Cited by-同舟云学术

Evaluation of the hepatotoxic potential of minocycline

Published:1991-07 Issue:7 Volume:35 Page:1434-1436
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Böcker R¹,Estler C J¹,Ludewig-Sandig D¹

Affiliation:

1. Institute for Pharmacology and Toxicology, University of Erlangen-Nürnberg, Federal Republic of Germany.

Abstract

Minocycline (25 to 100 micrograms/g) dose dependently increased serum glutamic oxalacetic transaminase, urea, and bilirubin levels, and the hepatic triglyceride content in mice. In animals pretreated with phenobarbital to enhance minocycline metabolism, the effects on liver triglycerides were attenuated, while the changes in serum glutamic oxalacetic transaminase, urea, and bilirubin were enhanced. It is concluded that part of the toxic effects of minocycline may be produced by a metabolite of minocycline.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.35.7.1434

Reference11 articles.

1. Bergmeyer H. U. and E. Bernt. 1970. Glutamat-Oxalacetat-Transaminase p. 685-710. In H. U. Bergmeyer (ed.) Methoden der enzymatischen Analyse 2nd ed. vol. 2. Verlag Chemie Weinheim Weinheim Federal Republic of Germany.

2. Comparative evaluation of the effects of tetracycline and doxycycline on blood and liver lipids of male and female mice;Bocker R.;Arzneim. Forsch.,1981

3. Comparative evaluation of the effects of tetracycline, rolitetracycline and doxycycline on some blood parameters related to liver function;Bocker R.;Arzneim. Forsch.,1982

4. Acute hepatic injury associated with minocycline;Burette A.;Arch. Intern. Med.,1984

5. Liquid chromatographic determination of minocycline in human serum;DeLeenheer A. P.;J. Pharm. Sci.,1979

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