Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines

Author:

Blagburn B L1,Sundermann C A1,Lindsay D S1,Hall J E1,Tidwell R R1

Affiliation:

1. Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849-5519.

Abstract

Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference19 articles.

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3. Current W. L. 1989. Cryptosporidium spp. p. 282-341. In P. D. Walzer and R. M. Genta (ed.) Parasitic infections in the immunocompromised host. Marcel Dekker Inc. New York.

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5. Current W. L. and B. L. Blagburn. 1990. Cryptosporidium: infections in man and domestic animals p. 155-185. In P. L. Long (ed.) Coccidiosis of man and domestic animals. CRC Press Inc. Boca Raton Fla.

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