Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection-Reference-Cited by-同舟云学术

Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection

Published:1998-04 Issue:4 Volume:36 Page:1113-1116
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Gerna Giuseppe¹,Zavattoni Maurizio¹,Percivalle Elena¹,Grossi Paolo²,Torsellini Maria²,Revello M. Grazia²

Affiliation:

1. Viral Diagnostic Service, IRCCS Policlinico San Matteo,1 and

2. Institute of Infectious Diseases, University of Pavia,2 Pavia, Italy

Abstract

ABSTRACT In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly ( P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly ( P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.36.4.1113-1116.1998

Reference17 articles.

1. Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study;Boeckh M.;Blood,1996

2. Quantitation of cytomegalovirus glycoprotein H gene in cells using competitive PCR and a rapid fluorescent-based detection system;Boivin G.;J. Virol. Methods,1995

3. Quantitation of human cytomegalovirus DNA using the polymerase chain reaction;Fox J. C.;J. Gen. Virol.,1992

4. Comparative quantitation of human cytomegalovirus DNA in blood leukocytes and plasma of transplant and AIDS patients

5. Correlation of quantitative human cytomegalovirus pp65-, p72- and p150-antigenemia, viremia and circulating endothelial giant cells with clinical symptoms and antiviral treatment in immunocompromised patients;Gerna G.;Clin. Diagn. Virol.,1993

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