Vibrio cholerae Strains with Mutations in an Atypical Type I Secretion System Accumulate RTX Toxin Intracellularly-Reference-Cited by-同舟云学术

Vibrio cholerae Strains with Mutations in an Atypical Type I Secretion System Accumulate RTX Toxin Intracellularly

Published:2004-12 Issue:23 Volume:186 Page:8137-8143
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Boardman Bethany Kay¹,Fullner Satchell Karla J.¹

Affiliation:

1. Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Abstract

ABSTRACT This study shows that the Vibrio cholerae RTX toxin is secreted by a four-component type I secretion system (TISS) encoded by rtxB , rtxD , rtxE , and tolC . ATP-binding site mutations in both RtxB and RtxE blocked secretion, demonstrating that this atypical TISS requires two transport ATPases that may function as a heterodimer.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.186.23.8137-8143.2004

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