Autism-Associated Vigilin Depletion Impairs DNA Damage Repair-Reference-Cited by-同舟云学术

Autism-Associated Vigilin Depletion Impairs DNA Damage Repair

Published:2021-06-23 Issue:7 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Banday Shahid¹,Pandita Raj K.²³,Mushtaq Arjamand¹,Bacolla Albino⁴^ORCID,Mir Ulfat Syed¹,Singh Dharmendra Kumar²,Jan Sadaf¹,Bhat Krishna P.⁵,Hunt Clayton R.²,Rao Ganesh³,Charaka Vijay K.²,Tainer John A.⁴⁶,Pandita Tej K.²³,Altaf Mohammad¹⁷^ORCID

Affiliation:

1. Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India

2. Houston Methodist Research Institute, Houston, Texas, USA

3. Baylor College of Medicine, Houston, Texas, USA

4. Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

5. Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

6. Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

7. Centre for Interdisciplinary Research and Innovations, University of Kashmir, Srinagar, Jammu and Kashmir, India

Abstract

Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, and mRNA stability and is associated with autism spectrum disorders and cancer: vigilin, for example, can suppress proto-oncogene c- fms expression in breast cancer. Conserved from yeast to humans, vigilin is an RNA-binding protein with 14 tandemly arranged nonidentical hnRNP K-type homology (KH) domains. Here, we report that vigilin depletion increased cell sensitivity to cisplatin- or ionizing radiation (IR)-induced cell death and genomic instability due to defective DNA repair.

Funder

DST | Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology, India

Foundation for the National Institutes of Health

HHS | NIH | NIH Clinical Center

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00082-21

Reference85 articles.